Herpes Simplex Virus 2 (HSV-2) is a member of the herpes virus family, Herpesviridae. HSV-2 has a relatively large double-stranded DNA genome. HSVs are primarily transmitted by sexual intercourse, direct contact with lesions or perinatally. Most HSV positive cases are characterised by lesions on the skins and mucous membranes of the mouth and genitals. HSV infection can be either primary or a recurrence of a previous infection. More than 90% of the primary HSV infections are asymptomatic. Primary infection with HSV-1 can lead to gingivostomatitis, eczema herpeticum, keratoconjunctivitis and encephalitis. The primary symptoms of a secondary infection are skin lesions in the nose, mouth and genital regions. The infection is contagious, mainly during an epidemic.
HSV-2 TaqMan PCR Kit, 100 reactions
HSV-2 TaqMan PCR Probe/Primer Set and Controls, 100 reactions
Figure 1 / 3
Click for expanded view
Storage Conditions and Product Stability
All kit components can be stored for 2 years after the date of production without showing any reduction in performance.
All kit components should be stored at -20°C upon arrival. Repeated thawing and freezing (> 2 x) of the Master Mix and Positive Control should be avoided, as this may affect the performance of the assay. If the reagents are to be used only intermittently, they should be frozen in aliquots.
| Component | Cat. TM32450 (100 preps) | Cat. TM32410 (100 preps) |
|---|---|---|
| MDx TaqMan 2X PCR Master Mix | 2 x 700 μL | – |
| HSV-2 Primer & Probe Mix | 280 μL | 280 μL |
| HSV-2 Positive Control | 150 μL | 150 μL |
| Nuclease-Free Water (Negative Control) | 1.25 mL | 1.25 mL |
| Product Insert | 1 | 1 |
| Clone | IHC411 |
| Source | Rabbit Monoclonal |
| Positive Control | Tonsil, Lung Adenocarcinoma |
| Dilution Range | 1:200 |
Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8 T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8 tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.
endo-BCN-PEG3-Gly represents an ADC linker featuring a BCN group, a hydrophilic PEG3 linker, and glycine residue. The BCN group is a click chemistry handle that readily reacts with azide groups on a target molecule to form stable triazole linkages. The PEG units enhance the aqueous solubility of the compound and may assist in fine-tuning DMPK properties. This compound may be applied to the synthesis of antibody-drug conjugates.
endo-BCN-PEG3-Gly represents an ADC linker featuring a BCN group, a hydrophilic PEG3 linker, and glycine residue. The BCN group is a click chemistry handle that readily reacts with azide groups on a target molecule to form stable triazole linkages. The PEG units enhance the aqueous solubility of the compound and may assist in fine-tuning DMPK properties. This compound may be applied to the synthesis of antibody-drug conjugates.