TIGIT is an immune receptor present on some T cells and Natural Killer cells. TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Through the CD226/TIGIT-PVR pathway, TIGIT regulates T cell mediated immunity. In cancer, TIGIT and PD-1 have been shown to be over-expressed on tumor antigen-specific CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of tumour antigen-specific CD8+ T cells and TIL CD8+ T cells. It can be considered an immune checkpoint.
A transparent, optically clear, DMSO resistant, non-tacky film which adheres only when pressure is applied. It is non-pierceable and peelable. Clear plastic, reflective, glossy on the top. Very thin and light and doesn’t crease easily.
A transparent, optically clear, DMSO resistant, non-tacky film which adheres only when pressure is applied. It is non-pierceable and peelable. Clear plastic, reflective, glossy on the top. Very thin and light and doesn’t crease easily.
Column accessories
Ordering information
| CAT NO. | PRODUCT NAME | SIZE | PRICE |
| C13200 | 2ml Collection Tubes | 1000/Bag | $70.00 |
| C13201 | 15ml Collection Tubes (15ml Centrifuge Tubes) | 100/Bag | $52.00 |
| C13202 | 50ml Collection Tubes (50ml Centrifuge Tubes) | 100/Bag | $52.00 |
| C13203 | 50ml Collection Tubes C (50ml High Speed Centrifuge Tubes) | 100/Bag | $68.00 |
| C13205 | 1.6ml Collection Plate | 100/Bag | $520.00 |
| C13301 | Vac Connectors | 100/Bag | $46.00 |
| C13302 | Extender Tubes | 50/Bag | $46.00 |
| C13303 | CockStop | 50/Bag | $208.00 |
Column accessories
The Opentrons Flat Bottom Aluminum Block can be placed directly on the OT-2/Opentrons Flex deck or on the Opentrons Temperature Module. This block can hold flat bottom plates and other flat labware at constant temperature. The aluminum block holds temperatures between 4°C and 95°C when used with the Opentrons Temperature Module (GEN2). This version is only compatible for the Opentrons Flex.
The Opentrons Flat Bottom Aluminum Block can be placed directly on the OT-2/Opentrons Flex deck or on the Opentrons Temperature Module. This block can hold flat bottom plates and other flat labware at constant temperature. The aluminum block holds temperatures between 4°C and 95°C when used with the Opentrons Temperature Module (GEN2). This version is only compatible for the Opentrons Flex.
