GeneAb™ PD-L1

Propargyl-PEG7-acid is a reagent with a propargyl group with a carboxylic acid. The carboxylic acid reacts with primary amines under the activation of EDC or HATU. The propargyl group can participate in azide-alkyne Click Chemistry reaction to form triazole linkage, copper is required as a catalyst. The PEG spacer increases the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Propargyl-PEG7-acid is a reagent with a propargyl group with a carboxylic acid. The carboxylic acid reacts with primary amines under the activation of EDC or HATU. The propargyl group can participate in azide-alkyne Click Chemistry reaction to form triazole linkage, copper is required as a catalyst. The PEG spacer increases the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Safety Features

1. User-Friendly Design: The chamber lid and tabletop are covered with heat-insulating resin materials, providing both protection against burns and an aesthetically pleasing appearance. The upward-opening flip-top door saves space, while the rounded corners prevent injury. The specially designed steam discharge and collection system minimizes steam burn risks and enhances operational convenience.

2. Interlock Mechanism and Safety Protection: The safety interlock system is designed to be more sensitive and secure. The chamber lid cannot be opened if there is pressure or steam inside the chamber. The lid can only be opened when the pressure gauge reads “0” MPa. The sterilizer will not start heating if the chamber lid is not properly locked. These features enhance the overall safety of the machine.

3. Over-temperature and Heating Protection: The system continuously monitors the temperature inside the sterilization chamber. If the temperature becomes too high or heating is abnormal, power will be automatically cut off to prevent overheating.

4. Automatic Fault Detection System: The machine performs an automatic self-check when powered on. If a fault occurs during operation, an audible alarm will sound, and a fault code will be displayed.

5. Lid Closure Check System: The system automatically detects whether the chamber lid is securely locked. If the lid is not properly locked, the sterilizer will not start.

6. Leakage, Over-current, and Short-Circuit Protection: If there is leakage in the heating elements or other components, or if over-current or short-circuit conditions occur, the system will automatically cut off power to prevent user injury.

7. Water Shortage and Independent Dry-Burning Protection: Equipped with a low water level sensor and independent dry-burning protection device, the system can monitor the water level in the chamber in real-time to prevent dry burning and avoid false readings. If the low water level sensor fails, the overheat and dry-burning protection system will automatically activate, cut off power to the heating ring, and sound an alarm to ensure safety.

8. Dual Pressure Protection: The system includes both a mechanical safety valve and an electronic over-pressure protection system. If pressure becomes abnormal, the system will relieve pressure and cut off power while sounding an alarm.

9. Back end Safety Testing: The system can be periodically tested for safety and protective measures.

10. Over-pressure Testing: Regular testing ensures that the instrument’s over-pressure protection system can automatically cut off power or that the safety valve can open to relieve pressure.

11. Performance Testing: The instrument’s safety performance has been tested by national authorized inspection agencies, and a test report is available.

Technical Parameters

Model	HB65A Standard TypeHB65B  Auto Water Replenishment TypeHB65C Auto Drying Type	HB90AStandard TypeHB90BAuto Water Replenishment TypeHB90CAuto Drying Type	HB110AStandard TypeHB110BAuto Water Replenishment TypeHB110CAuto Drying Type
Capacity	65L	90L	110L
Dimensions (L × W × H) mm	664×660×994.5	664×660×994.5	664×660×1200
Sterilization Chamber Dimensions (Diameter × Height) mm	φ400×530	φ400×730	φ400×920
Rated Power	2800W	3400W	4500W
Rated Voltage	220V±10%50Hz
Temperature Display Accuracy	0.1℃
Operating Environment	5℃~40℃、Relative Humidity10%～85%
Sterilization Chamber Material	SUS304Stainless Steel
Sterilization Working Temperature	105℃~143℃
Sterilization Time Pre-set Range	1minute ～9999minutes
Melting Temperature Pre-set Range	60℃~100℃
Melting Time Pre-set Range	1minute～9999minutes
Insulation Temperature Pre-set Range	45℃~60℃
Insulation Time Pre-set Range	1minute～9999minutes
Door Opening Temperature Pre-set Range	Solid, Agar, and Waste Modes: 40°C ~ 99°C        Liquid Mode: 40°C ~ 80°C
Clock FunctionTimer Pre-set Range	Timer Pre-set Range: Set operating time (year, month, day, hour, minute), check current time (year, month, day, hour, minute), total sterilization cycles, fault occurrence time, and code.
Pressure Gauge Display Range	0～0.6Mpa
Pressure	Chamber Design Pressure: 0.35 MPa; Each product comes with a quality certificate and a certificate issued by the special equipment manufacturing supervision and inspection department.
Pressure Safety Protection	Dual independent pipeline measurement and control, mechanical and electronic dual pressure protection
Sterilization Modes	·  Solid Mode: Heating → Sterilization → Exhaust, Air Cooling·  Solid with Drying Mode: Heating → Sterilization → Drainage, Exhaust → Drying·  Liquid Mode: Heating → Sterilization → Pre-cooling → Exhaust·  Liquid with Insulation Mode: Heating → Sterilization → Pre-cooling → Exhaust → Insulation·  Waste Mode: Heating → Sterilization → Exhaust, Air Cooling·  Agar Mode: Heating → Melting → Insulation
Exhaust Control and Water Tank	Fully automatic internal exhaust (see instructions for exhaust temperature settings), built-in large-capacity steam condensate collection bottle and water tank
Cover Opening Method and Interlocking Device	Unique eight-column interlocking device, flip-cover switch, touch-type handle
Controller and Memory Storage Function	Microcomputer intelligent control system. 6 fixed operation modes, 82 modifiable modes, 88 memory storage programs
Safety Devices	Door lock interlocking device; Cover closing check; Dry burn protection; Water level sensor monitoring; Electronic over pressure protection; Mechanical safety valve; Over temperature and heating protection; Over current and short circuit protection; Leakage protection; Cooling lock; Burn injury safety protection; Automatic fault detection system
Accessories	Condensate collection bottle, water separation plate, drainage hose, stainless steel basket
Optional Accessories	Printer, cooling fan, item temperature sensor, USB output
Stainless Steel Baskets	(φ360×230)1pcs(φ360×200)1pcs	(φ360×200)1pcs(φ360×400)1pcs		(φ360×200)2pcs(φ360×400)1pcs

Note: The upper limits for cooling lock door temperature and exhaust temperature are related to the boiling point.

Other Optional Accessories

1. Dot Matrix Printer: Capable of printing temperature, time, F0 value, and pressure data. USB data export and curve plotting.

2. Stainless Steel Basket with Base.

3. Pressure Sensor

4. Stainless Steel Bucket

5. Item Thermometer

6. 3Q Validation Adapter

Features and functions:

1. Large-diameter sterilization chamber：The 40 cm large-diameter sterilization chamber provides an exceptionally spacious environment to meet a wide range of sterilization needs.

2. Sterilization temperature：105-138℃.

3. Exhaust control ：After sterilization is complete, the exhaust valve can automatically open to release the exhaust at a pre-set temperature.

4. Verification interface: Provides temperature and pressure inspection ports for easy calibration.

5. Saturated steam monitoring：The system automatically monitors the expulsion of cold air to ensure a pure steam sterilization environment, guaranteeing optimal sterilization effectiveness.

6. Pressure performance：The chamber is designed to withstand a pressure of up to 0.35 MPa, and each unit is tested with a water pressure of up to 0.44 MPa. Advanced pressure protection ensures the safety load of the equipment.

7. Intelligent control system:The microcomputer chip-based intelligent control system monitors the temperature and pressure inside the sterilization chamber in real-time. The chamber lid can only be opened under safe temperature and pressure conditions. The system also provides fully automatic control of the sterilization process and allows for convenient maintenance, inspection, calibration, recording, and future upgrades.

8. Six preset programs:Includes six fixed programs for liquid sterilization and holding, solid sterilization and drying, agar melting and holding, and waste sterilization.

9. Memory storage system:Users can set their own parameters, create multiple programs, and access them at any time. The system allows for operation permissions to be set at three levels—user, administrator, and engineer—to facilitate effective use and management of the sterilizer.

10. Door-opening temperature: Each program can be set with a specific cooling lock door-opening temperature based on the thermal inertia of the sterilized items. This prevents users from opening the door when the items (especially liquid sterilized items) are still in an unsafe condition, thus avoiding burns.

11. Drying function: Thorough drying that meets CE standards, with a cooling lock mechanism.

12. One-touch inquiry function: Allows checking of current time, total number of sterilization cycles, fault occurrence time, and codes.

13. Scheduled start function: Allows you to set a start time so that the sterilizer automatically starts at the scheduled time.

Model:
HB65/ HB90/ HB110

Compact and stylish designed, the BioShake iQ high-end thermoshaker lets you perform all your standard mixing runs with a minimum of adjustments.
The BioShake iQ offers outstanding performance to handle a wide range of applications across biotechnology, pharmaceutical and academic research.

Small. Light. Efficient. Quiet.

• For microplates, tubes and glass vials
• Fast & high-precision heating
• Temperature range: ambient to 99°C
• Precise mixing from 200 – 3,000 rpm
• Wide range of thermo adapters
• Stylish aluminium housing

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ADVANCED TECHNOLOGY

Save time.

By combining the mixing operation with the incubation phase, reaction process times and operator workload are reduced and efficiency of many procedures is increased, resulting in a higher throughput.

The first-class finished aluminium housing gives the BioShake iQ its essential functionality. It provides a high amount of security, device stability and ensures a long service life.

GENTLE MIXING OF SAMPLES

By planar orbital motion

German designed and manufactured, BioShake iQ thermoshaker offer an ultra-efficient, 2-dimensional shaking axis so that samples mix completely in a fraction of the time of competing systems.

The mixing orbit of 2.0 mm is always constant. The orbital shaking is precisely controlled, in fact, that you need never spin down your plates after mixing. Even tubes, vials, high density plates, or low sample volumes, offer no obstacle for these precision tools.

Fully adjustable between 200 rpm and 3,000 rpm, well beyond the speeds of most other brands, guarantees fast, splatter-free, mixing for tubes, glass vials or across an entire 384-well microplate.

HOMOGENEOUS HEATING

Using large-area heating source in combination with digital sensor electronic

The BioShake iQ heats from ambient to 99°C in a short time, provides ease of use features, amazing comfort and maximum safety.

Within the BioShake iQ thinnest large-area heating elements and sensors are integrated. During the heat up time the special electronic control system guarantees the same temperature for all vessels with minimal deviations.
Temperatures are selectable from ambient temperature to 99°C in steps of 1.0°C. The nominal regulation accuracy is better than ±0.1°C with a uniformity of temperature distribution better than ±0.5°C at 45°C across the heating surface.

Exchangeable thermo adapter plates and thermal blocks enable a perfect adaptation to microplates, tubes or glass vials.

UNIVERSAL SPRING CLAMPS

Suitable for all microplates

In the corners eight spring clamps are inserted for easy fixation of skirted microplates and deep well plates in SBS format 127.7 x 85.5 mm without an attached adapter. These spring clamps lock the microplate quickly and safely, even at the highest mixing frequencies.

For flexible and deformable PCR plates we recommend using of the related PCR adapter.

Fast mixing processes with frequent plate changes can be performed in the routine as easy and safe.

COMFORT

Simple intuitive operation and programming

The BioShake iQ is operated from the front face of the enclosure which includes touch buttons and a display. 

Special buttons for start, stop and storage of time and mixing modes enable the instrument to run complex applications. This opens new points of view on the daily laboratory work and optimizes routine application enormously.

The short mix button allows short and fast mixing in between.

The two line LCD display guarantees simultaneous and safe reading of all programmed and measured parameters as time, mixing frequency and temperature.

EXCHANGABLE THERMO ADAPTERS

For a wide range of applications

The BioShake iQ comes with a variety of standardized and specific adapter plates. The replacement of the adapters are very simple.

Perfect shaped adapters allow an optimal fit for standard tubes, lysis tubes, microplates, glass vials and other sample vessels. An excellent temperature uniformity and homogeneity is guaranteed for all samples.

UNIQUE DESIGN MEETS HIGH-END TECHNOLOGY

First-class finished aluminium housing

Unique and efficient design combined with the most compact housing result in beautiful and well-defined laboratory equipment. Therefore, the first-class finished aluminium housing gives the BioShake iQ its essential functionality. It provides a high amount of security, device stability and ensures a long service life.

Safety of the user and ease of use are clearly a priority.

MADE IN GERMANY

High-end instruments for daily routine

A perfectly harmonious blend of high-tech and handmade. “Made in Germany” has always been a recipe for success for QInstruments. 100% of QInstruments production takes place in Germany.

The focus is on human diligence and on being environmentally friendly. The company upholds its quality guarantee by means of consistent quality management. For more than 15 years these lab automation professionals from Jena have used only high-quality materials to ensure sustainable production, applied innovative thinking and undertaken research in a future-oriented way – all as a matter of course.

For microplates, tubes and glass vials
Fast & high-precision heating
Temperature range: ambient to 99°C
Precise mixing from 200 – 3,000 rpm
Wide range of thermo adapters
Stylish aluminium housing